Computational Biochemist | Bridging Protein Structure & Multi-Omics | Ribosomal Translocation Mechanisms
Founder & Principal Investigator
AI models and pipelines to predict how genetic variants affect protein structure, stability, dynamics, and function.
Deep Learning • pQTL Mapping • Multi-omics
Mapping structural consequences of genetic variation using AlphaFold, MD simulations, and experimental structure determination.
AlphaFold • Cryo-EM • MD Simulations
Applying genoproteomics to precision medicine, drug discovery, and clinical diagnostics.
Pharmacogenomics • Biomarkers • Drug Targets
"The genome promised everything. It delivered half. Proteins are the true molecular machines of life. Genoproteomics systematically maps how genetic variants shape the complete proteome—not predictions, but direct, measurable, actionable protein phenotypes for precision medicine and drug discovery."
Research & Teaching Positions
Graduate Research Assistant (Wang Lab)
Department of Biology and Biochemistry, Houston, TX
Investigating the mechanism of ribosomal translocation using single-molecule FRET to dissect elongation factor function during translation.
Studying translational GTPases (e.g., EF-G) to understand how these factors coordinate movement of tRNA and mRNA on the ribosome.
Building analysis workflows to interpret conformational states and dynamics during translation.
Supporting lab instrumentation, including liquid chromatography–mass spectrometry workflow (Waters UPLC-QDa) for RNA/oligo quality control and method optimization.
Graduate Teaching Assistant
Houston, TX
Instructional TA for Biochemistry I (BCHS 3304); led exam reviews, supported assessment, and covered metabolism, enzymology, protein structure, and kinetics.
Teaching Assistant for Introductory Biology labs (BIOL 1106); guided students in experimental technique, data handling, and safety (mentor: Dr. Ana Medrano).
Supported General / Organic Chemistry (CHEM 1106, 1112) lab sections: wet-lab technique, safety, and analytical reporting.
Project Intern
Pune, Maharashtra, India
Studied drug candidates that inhibit human islet amyloid polypeptide (hIAPP) relevant to Type 2 Diabetes.
Used INS-1E cell culture to analyze signaling proteins (AKT, Bax/Bcl-2) and assess apoptotic vs survival pathways.
Performed western blot analysis and ran molecular dynamics simulations (Modeller, GROMACS, NAMD, VMD).
Summer Research Intern
Pune, India
Research internship in small-molecule discovery targeting sickle cell disease.
Current & Recent Investigations
May 2023 – Present
Tools: single-molecule FRET, ribosome translocation assays, elongation factor functional analysis
Using single-molecule FRET to probe how elongation factors (e.g., EF-G) drive ribosomal translocation and maintain translation efficiency and fidelity.
Dissecting conformational changes during tRNA/mRNA movement on the ribosome.
May 2023 – Present
Tools: Python, R, ProDy, PyMOL, ChimeraX, IQ-TREE2
Built an automated pipeline for large-scale all-vs-all structural alignment of translational GTPase G-domains (EF-G, EF-Tu, EF-2, EF-4, TetM/O).
Calculated RMSD / TM-score matrices and mapped conserved "core" vs variable regions to infer evolutionary divergence.
Integrated structural clustering with phylogeny to propose how the ancestral G-domain diversified into modern translation factors.
Nov 2019 – Nov 2020
Tools: INS-1E cell culture, AKT/Bax-Bcl-2 signaling, western blotting, Modeller, GROMACS, NAMD, VMD
Screened small molecules targeting human islet amyloid polypeptide (hIAPP) aggregation relevant to Type 2 Diabetes.
Ran molecular dynamics simulations and analyzed signaling responses (AKT, Bax/Bcl-2) to evaluate therapeutic potential.
Research Outputs
View-Specific Preprocessing for Multi-Modal Integration Improves Breast Cancer Progression Prediction: A Machine Learning Analysis of TCGA-BRCA.
Preprint (SSRN), 2025.
DOI: 10.2139/ssrn.5876162
Multi-Omic Integration and Machine Learning Reveal Regulatory Networks Driving Breast Cancer Progression.
Preprint (Preprints.org), 2025.
Machine Learning-Guided Catalyst Selection Reveals Nickel's Advantages Over Palladium in Suzuki-Miyaura Cross-Coupling.
Preprint (ChemRxiv), 2025.
URL: ChemRxiv Preprint
Nickel Outperforms Palladium in Suzuki-Miyaura Cross-Coupling: A Machine Learning Analysis of Five Metal Catalysts
Preprint (ChemRxiv), 2025.
URL: ChemRxiv Preprint
Provider Logo Beyond Tool Access: A Systematic Review of Human–GenAI Interaction Patterns, Trade-offs, and Design Principles in Higher Education
Preprint (EdArXiv), 2025.
URL: EdArXiv Preprint
Open-Source Contributions
rnaview - Python Package for RNA Structure Visualization and Analysis
Python Package Index (PyPI), 2025.
Package: pypi.org/project/rnaview/1.0.1
Technical Expertise
Python (NumPy, pandas, scikit-learn), Bash; Git/GitHub; Linux/SLURM for HPC workflows; large-scale data handling.
Model training and analysis using PyTorch, TensorFlow, and Keras; classical ML with scikit-learn; dimensionality reduction (t-SNE, PCA); clustering and classification of structural/biophysical datasets.
Single-molecule FRET; structural visualization and analysis in PyMOL and UCSF ChimeraX.
UPLC–MS / LC–MS (Waters UPLC-QDa); method development and optimization; targeted SIR channel setup; RNA / oligonucleotide QC; troubleshooting peak quality and carryover.
MassLynx, TargetLynx, OpenLynx, Skyline (basic).
Mammalian cell culture (INS-1E); pathway interrogation of AKT and Bax/Bcl-2; apoptosis/survival assays; western blotting and densitometric interpretation.
Basic NGS analysis workflows; RNA handling; docking and molecular dynamics simulations (Modeller, GROMACS, NAMD, VMD).
Led Biochemistry I recitation sessions; supported Intro Biology, General Chemistry, and Organic Chemistry teaching labs; mentored summer interns (Welch Foundation).
Academic Background
University of Houston
Houston, TX, USA | Aug 2022 – 2025
Research area: structural biochemistry of translation, ribosome translocation, and translational GTPases.
Fergusson College (Autonomous)
Pune, India | 2018 – 2020
Focus: molecular biology, protein biochemistry, signaling, and disease pathways.
Savitribai Phule Pune University
Pune, India | 2014 – 2018
Recognition & Funding